An extension to synphot (ascl:1811.001), stsynphot implements synthetic photometry package for HST and JWST support. The software constructs spectra from various grids of model atmosphere spectra, parameterized spectrum models, and atlases of stellar spectrophotometry. It also simulates observations specific to HST and JWST, computes photometric calibration parameters for any supported instrument mode, and plots instrument-specific sensitivity curves and calibration target spectra.