pysynphot is a synthetic photometry software package suitable for either library or interactive use. Intended as a modern-language successor to the IRAF/STSDAS synphot package, it provides improved algorithms that address known shortcomings in synphot, and its object-oriented design is more easily extensible than synphot's task-oriented approach. It runs under PyRAF (ascl:1207.011), and a backwards compatibility mode is provided that recognizes all spectral and throughput tables, obsmodes, and spectral expressions used by synphot, to facilitate the transition for legacy code.