nbodykit provides algorithms for analyzing cosmological datasets from N-body simulations and large-scale structure surveys, and takes advantage of the abundance and availability of large-scale computing resources. The package provides a unified treatment of simulation and observational datasets by insulating algorithms from data containers, and reduces wall-clock time by scaling to thousands of cores. All algorithms are parallel and run with Message Passing Interface (MPI); the code is designed to be deployed on large super-computing facilities. nbodykit offers an interactive user interface that performs as well in a Jupyter notebook as on super-computing machines.