ISIS is a complete package to process CCD images using the image Optimal subtraction method (Alard & Lupton 1998, Alard 1999). The ISIS package can find the best kernel solution even in case of kernel variations as a function of position in the image. The relevant computing time is minimal in this case and is only slightly different from finding constant kernel solutions. ISIS includes as well a number of facilities to compute the light curves of variables objects from the subtracted images. The basic routines required to build the reference frame and make the image registration are also provided in the package.