pyC²Ray updates C²-Ray (ascl:2312.022), an astrophysical radiative transfer code used to simulate the Epoch of Reionization (EoR). pyC²Ray includes a new raytracing method, ASORA, developed for GPUs, and provides a Python interface for customizable use of the code. The core features of C²-Ray, written in Fortran90, are wrapped using f2py as a Python extension module, while the raytracing library ASORA is implemented in C++ using CUDA. Both are native Python C-extensions and can be directly accessed from any Python script.