ExoSim 2 (Exoplanet Observation Simulator 2) makes spectro-photometric observations of transiting exoplanets from space, ground, and sub-orbital platforms. It is a complete rewrite of ExoSim (ascl:2002.008); it is implemented in Python 3 and uses object-oriented design principles. The package follows a three-step workflow: the creation of focal planes, the production of Sub-Exposure blocks, and the generation of non-destructive reads (NDRs). ExoSim 2 has demonstrated consistency in estimating photon conversion efficiency, saturation time, and signal generation. The simulator has also been validated independently for instantaneous read-out and jitter simulation, and for astronomical signal representation.