pyEFPE implements a frequency-domain post-Newtonian waveform model for inspiralling, precessing, eccentric compact binaries. The code computes gravitational-wave signal templates by interpolating analytical Fourier-mode amplitudes and incorporating post-Newtonian corrections to enhance numerical stability and computational speed. It provides a user interface that accepts binary system parameters such as masses, spins, and eccentricity, and returns waveform data suitable for data-analysis applications. Designed for gravitational-wave astronomy, pyEFPE enables efficient waveform generation for eccentric, spin-precessing binaries.