TRIPP (TRansient Image Processing Pipeline) detects transients and variable sources using difference imaging analysis and light-curve analysis techniques. It performs image registration, subtraction, and source extraction, producing photometric measurements and light curves for candidate events. Designed for use with networks of small telescopes and large synoptic surveys, the pipeline enables (near) real-time identification of transient phenomena. Though written specifically with LGTS in mind, the pipeline and its optimizations could be broadly beneficial for time-domain astrophysics; TRIPP could feasibly detect OSETI signals in LGTS data.