PyRAF is a command language for running IRAF tasks that is based on the Python scripting language. It gives users the ability to run IRAF tasks in an environment that has all the power and flexibility of Python. PyRAF can be installed along with an existing IRAF installation; users can then choose to run either PyRAF or the IRAF CL.

The Space Telescope Science Data Analysis System (STSDAS) is a software package for reducing and analyzing astronomical data. It is layered on top of IRAF and provides general-purpose tools for astronomical data analysis as well as routines specifically designed for HST data. In particular, STSDAS contains all the programs used for the calibration and reduction of HST data in the STScI post-observation processing pipelines.