DeepSphere implements a generalization of Convolutional Neural Networks (CNNs) to the sphere. It models the discretized sphere as a graph of connected pixels. The resulting convolution is more efficient (especially when data doesn't span the whole sphere) and mostly equivariant to rotation (small distortions are due to the non-existence of a regular sampling of the sphere). The pooling strategy exploits a hierarchical pixelization of the sphere (HEALPix) to analyze the data at multiple scales. The graph neural network model is based on ChebNet and its TensorFlow implementation.