Tangos builds databases (along the lines of Eagle or MultiDark) for cosmological and zoom simulations. Its modular system generates and queries databases. It is designed to store and manage results from a user's own analysis code, provides web and python interfaces, and allows users to construct science-focused queries, including across entire merger trees, without requiring knowledge of SQL. Tangos manages the process of populating the database with science data, including auto-parallelizing the analysis. It can be customized to work with multiple python modules such as pynbody (ascl:1305.002) or yt (ascl:1011.022) to process raw simulation data; it defaults to using SQLite, but allows use of other databases as the underlying store through the use of SQLAlchemy.